Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers
نویسندگان
چکیده
منابع مشابه
Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.
The clinical use of therapeutic hypothermia has been rapidly expanding due to evidence of neuroprotection. However, the effect of hypothermia on specific pathways of drug elimination in humans is relatively unknown. To gain insight into the potential effects of hypothermia on drug metabolism and disposition, we evaluated the pharmacokinetics of midazolam as a probe for CYP3A4/5 activity during ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2010
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.109.031377